Factor X deficiency:

An uncommon presentation of AL amyloidosis

Coagulopathies resultant from clotting factor deficiencies can be roughly split into two categories; heritable and acquired.

A reduction in the synthesis or the destruction of individual clotting factors can be caused by a number of genetically inherited mutations. The most common form of heritable factor deficiency is Haemophilia A, where the production of Factor VIII is compromised by an X-linked recessive mutation.

Factor deficiency can also be acquired by the inhibition of clotting factors or reducing their rate of production in patients without genetic defects. The most common acquired deficiencies are Liver disease, systemic lupus erythematosus and anticoagulation.

Helena Biosciences have an extensive range of analytical reagents and factor deficient plasmas for use in the identification of congenital and acquired factor deficiencies.

Read more: https://www.helena-biosciences.com/en/news/2015/june-factors/

Why Perform Platelet Aggregation?

Platelet aggregation, the process by which platelets adhere to other platelets at sites of vascular injury.

Platelet aggregation, the process by which platelets adhere to other platelets at sites of vascular injury, has long been recognised to be critical for haemostatic plug formation and thrombosis. Haematology laboratories perform platelet aggregation testing to diagnose specific bleeding disorders when a patient sample gives abnormal results to routine coagulation assays.

Read more: https://www.helena-biosciences.com/en/news/2015/why-perform-platelet-aggregation/


ISTH recommends D-Dimer test for new COVID-19 admissions

In new guidance published recently by the International Society on Thrombosis and Haemostasis, D-Dimer (among other coagulation tests) is recommended as a routine stratification tool upon admission to hospital.

Read more: https://www.helena-biosciences.com/en/news/2020/hn0062/